Registration Dossier
Registration Dossier
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EC number: 242-362-4 | CAS number: 18479-58-8
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Details on study design: HPLC method:
- HPLC parameters:
- HPLC system: Agilent Technologies 1050/1100, incorporating autosampler and workstation
- Column: Hypersil Gold CN (150 x 4.6 mm id)
- Column temperature: 35 degrees C
- Mobile phase: methanol:water (55:45 v/v_
- pH of mobile phase: 7.0 adjusted with 0.1M sodium hydroxide
- Flow-rate: 1.0 ml/min
- Injection volume: 10 ul
- UV detector wavelength: 210 nm - Type:
- Koc
- Value:
- 177.83
- Temp.:
- 35 °C
- Remarks on result:
- other: Assumed to have been determined at NTP
- Type:
- log Koc
- Value:
- 2.25
- Temp.:
- 35 °C
- Remarks on result:
- other: Assumed to have been determined at NTP
- Details on results (HPLC method):
- See table 1 (in 'remarks and results including tables and figures' field) for retention times, capacity factors and log Koc values for each sample.
- Transformation products:
- not measured
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of this study, the adsorption coefficient of the test item is 177.83 (log koc = 2.25)
Reference
Table 1. Retention time, capacity factors and log Koc values for each sample.
| Injection | Retention time (minutes) | Capacity factor (k) | Log K | Log10Koc | Mean Log10Koc |
| 1 | 2.939 | 0.425 | -0.372 | 2.25 | 2.25 |
| 2 | 2.938 | 0.424 | -0.372 | 2.25 |
Description of key information
The adsorption coefficient (Koc) was determined by application of EC Method C19/OECD 121 (HPLC method).
Key value for chemical safety assessment
- Koc at 20 °C:
- 177.83
Additional information
Under the conditions of this study, the adsorption coefficient was 177.83: Log Koc = 2.25 (determined at 35 degrees C using HPLC).
[LogKoc: 2.25]
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