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EC number: 911-238-8 | CAS number: -
One hour up to 48 respectively 72 hours after administration the animals showed some definitely injected blood vessels up to diffuse beefy red color. Obvious swellings of the conjunctivae with partial eversion of lids was noted in all animals 1 hour after application. 24 hours after administration two animals showed slight swellings. One animal showed a moderately reddened iris 24 hours after administration. One hour after administration one animal showed serous eye discharge discolored by the compound. The two other animals showed white mucous eye discharge. 7 days after administration all signs of irritation had disappeared.
1 hour after treatment
24 hours after treatment
48 hours after treatment
72 hours after treatment
7 days after treatment
An amount of 100 mg Resin 835 A (Lot: 0161852) was administered once to the conjunctival sac of the left eye of three female New Zealand White rabbits. The treated eyes were washed out 24 hours after the administration of the test substance. The untreated eyes served in each case as a control.
The test substance caused no severe irritating effects in the eyes of the animals.
Based on the system of evaluation defined by the EC, the following group mean scores for ocular lesions after 24, 48 and 72 hours were calculated:
Redness of conjunctiva : 1.22
Opacity of cornea : 0.0
Chemosis of conjunctiva : 0.22
Iris : 0.11
No clinical signs of systemic toxicity were observed.
Summarizing, testing for primary eye irritation in the rabbit showed that Resin 835 A (Lot: 0161852) is not irritating to eyes according to the classification criteria of Directive 2001/59/EC.
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