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Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1990-01-31
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 105
Deviations:
yes
Remarks:
Organic solvents were used instead of water.
GLP compliance:
yes (incl. QA statement)
Key result
Medium:
isopropanol
Solubility:
> 210 g/L
Temp.:
20 °C
Key result
Medium:
acetone
Solubility:
> 210 g/L
Temp.:
20 °C
Key result
Medium:
methanol
Solubility:
> 210 g/L
Temp.:
20 °C
Key result
Medium:
ethyl acetate
Solubility:
> 210 g/L
Temp.:
20 °C
Key result
Medium:
other: n-Hexane
Solubility:
2.4 mg/L
Temp.:
20 °C
Key result
Medium:
other: Dichloromethane
Solubility:
410 mg/L
Temp.:
20 °C
Key result
Medium:
toluene
Solubility:
670 mg/L
Temp.:
20 °C
Test substance stable:
yes
Conclusions:
Cyanamid F1000 is highly soluble in polar solvents and only slightly soluble in non-polar solvents.
Executive summary:

The study examined the solubility of Cyanamid F1000 in organic solvents (of the DAPA list) by the modified flask method according to the OECD Guideline 105. The solubility examination was limited by the BBA classification (danger characterization of the solvents) to 0.1 g/L – 200 g/L. The solubility of Cyanamid F1000 in polar solvents, i-Propanol, Aceton, Methanol and Ethylacetate was measured to be above 210 g/L, while in the non-polar solvents, n-Hexan, Dichlormethan and Toluene the solubility of Cyanamid F1000 was found to be lower than 1 g/L ( 2.4, 410, 670 mg/L respectively). It can be concluded that cyanamide is highly soluble in polar solvents and only slightly soluble in non-polar solvents. These results could be also predicted on the basis of the chemical structure of the cyanamide molecule. It is not to be expected that these values would significantly change with increasing or decreasing temperatures.

Description of key information

Cyanamid F1000 is highly soluble ( > 210 g/L) in polar solvents and only slightly soluble (< 1 g/L) in non-polar solvents.

Key value for chemical safety assessment

Additional information

The study examined the solubility of Cyanamid F1000 in organic solvents (of the DAPA list) by the modified flask method according to the OECD Guideline 105. The solubility examination was limited by the BBA classification (danger characterization of the solvents) to 0.1 g/L – 200 g/L. The solubility of Cyanamid F1000 in polar solvents, i-Propanol, Aceton, Methanol and Ethylacetate was measured to be above 210 g/L, while in the non-polar solvents, n-Hexan, Dichlormethan and Toluene the solubility of Cyanamid F1000 was found to be lower than 1 g/L ( 2.4, 410, 670 mg/L respectively). It can be concluded that cyanamide is highly soluble in polar solvents and only slightly soluble in non-polar solvents. These results could be also predicted on the basis of the chemical structure of the cyanamide molecule. It is not to be expected that these values would significantly change with increasing or decreasing temperatures.