Registration Dossier
Registration Dossier
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EC number: 205-571-1 | CAS number: 142-91-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up the limit of water solubility
Key value for chemical safety assessment
Additional information
In general, all EC50(48h) values in the category, derived with different invertebrate species for various test substances that belong to the category have been found above the limit of water solubility, so that no direct toxicity of dissolved substance was found (chemical toxicity). There were, however, several descriptions of indirect toxicity by physical effects of the test substance at concentrations between 1 and 100 mg/L.
In the key study, the acute toxicity of Isopropyl palmitate to Daphnia magna was tested under static conditions according to EU Method C.2 and to GLP (Kirch 1998), using a solution of test material after removal of undissolved test material of 1000 and 3000 mg/L (nominal). No immobilized Daphnids were found, however animals were swimming in both concentrations on the surface, respectively. Since the analytical recovery rates were below 0.1%, the resulting EC50(48h) was related to the nominal concentration (>3000 mg/L).
In further read-across from Isopropyl oleate (CAS 112-11-8), the acute toxicity to the marine species Crangon crangon was tested under constant stirring (Clitherow 1991). Part of the test sample was observed to remain on the liquid surface, even with continuous stirring. The agitation was sufficient to maintain a distribution within the body of the liquid, but at higher concentrations the thickness of the floating layer increased. No mortalities occured up the highest concentration tested, 8500 mg/L.
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