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EC number: 245-205-8 | CAS number: 22766-83-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of 2-octyldodecyl
myristate (CAS 22766-83-2) to aquatic algae are available, in accordance
to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the
structurally related source substance 2-octyldodecyl isooctadecanoate
(CAS 93803-87-3) was conducted. The source substance is representative
to evaluate the short-term toxicity of the target substance to fish. The
target substance is characterised as an ester of C18 iso branched fatty
acid esterified with 2-octyldodecan-1-ol. The source substance is
structurally very similar to the target substance. 2-octyldodecyl
isooctadecanoate (CAS 93803-87-3) is characterised by a longer fatty
acid chain length (C18 iso branched) and by the same alcohol component
(2-octyldodecan-1-ol).
This read-across is justified in detail in the overall summary (IUCLID
Section 6.1) and within the analogue justification in IUCLID Section 13.
In this case of read-across, the best suited (highest degree of
structural similarity, nearest physico-chemical properties) read-across
substance was used for the assessment.
The study with the source substance 2-octyldodecyl isooctadecanoate (CAS
93803-87-3) to aquatic algae was performed according to OECD 201 (GLP)
with the freshwater algae Selenastrum capricornutum (Bogers, 1998).
Water Accommodated Fractions (WAF) of nominal 10 and 100 mg/L were
prepared and tested under static conditions. A chemical analysis of the
test substance concentrations in the test vessels was not possible since
no applicable method could be established due to the very low water
solubility to detect test concentrations. An inhibition of cell growth
(31.2%) was observed after 72 h in the WAF test solution of 100 mg/L,
whereas no inhibition was observed in the WAF test solution of 10 mg/L.
It was reported that this effect is probably related to insoluble
particles which might have adsorbed fractions of light needed for algal
cell growth. However, the growth rate was not inhibited resulting in an
EL50 (72 h) of > 100 mg/L and a NOELR (72 h) of ≥ 100 mg/L.
Based on the available results from structurally related read-across
substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5)
which is characterised by a comparable structure, it can be concluded
that 2-octyldodecyl myristate will not exhibit effects on aquatic algae
up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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