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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available

Data source

Reference
Reference Type:
secondary source
Title:
Submission of data by CTFA (2-5-21), CIR safety test data summary, primary skin irritation of monoethanolamine
Author:
CTFA
Year:
1944
Bibliographic source:
cited in: CIR (1983): J. Am. Coll. Toxicol. 2, pp. 205 - 207

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test substance was repeatedly applied in a total of 10 exposures over a period of 14 days to the skin of rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): monoethanolamine
- purity:> 99 %

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
not specified
Details on exposure:
Route of Administration: dermal
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 1-100 %

Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
2 weeks
Frequency of treatment:
10 applications on working days over a 2-week period
Doses / concentrations
Remarks:
Doses / Concentrations:
1 - 100 % solution/application
Basis:
no data
No. of animals per sex per dose:
unspecified
Control animals:
not specified
Positive control:
none

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

10 % or higher was corrosive to the skin, >1 % was extremely irritating to the skin and 1 % was irritating to the skin. No further data given.

Applicant's summary and conclusion