Registration Dossier
Registration Dossier
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EC number: 205-483-3 | CAS number: 141-43-5
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The most sensitive NOEC was derived from an early life stage test in 1996 with 1.2 mg/L.
Key value for chemical safety assessment
Additional information
The long-term effects of MEA (CAS 141 -43 -5) were studied in an early lifestage test according to OECD 210 performed by the Ministry of the Environment in Japan (NITE, 2008). Oryzias latipes was used as the test species. The fish (eggs) were exposed in a flow-through system. The test concentrations were analytically verified and showed to be stable over the exposure period. The 41-d NOEC was 1.24 mg/L (measured).
This result is supported by a prolonged fish test with Oryzias latipes conducted according to OECD 204 (NITE, 1997). The 14-d NOEC (mortality) was > 100 mg/L (measured).
Mayer et al. (1986) determined the 100-d NOEC for reproduction, percent hatch and percent viability of Salvelinus fontinalis to be 1.77 mg/L. The 100 -d NOEC for survival, length, weight of this species was > 20 mg/L. Test concentrations were not analytically verified, however, the test was performed with a flow-through system and tests with chemical analysis showed an acceptable recovery of the test item in the test solutions. In addition, the substance is highly water soluble, is not expected to evaporate rapidly into the atmosphere (Henry's law constant < 1 Pa*m³/mol) and adsorption is also not expected.
Based on the available effect data long-term effects are not to be expected.
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