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Partition coefficient

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Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
The result was obtained using an appropriate QSAR method (see attached QMRF and QPRF for details).
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
3.4
Temp.:
25 °C
pH:
7

Estimated value, no data available for temperature and pH

Conclusions:
An octanol-water partition coefficient value of 3.4 was obtained using an accepted calculation method. The result is considered to be reliable.
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Principles of method if other than guideline:
method not stated
GLP compliance:
no
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
2.99

Value from peer-reviewed secondary source, no data available for temperature and pH.

Conclusions:
A partition coefficient value of 2.99 is reported in secondary literature (handbook). The original reference was not available for review and no further information is available. The reliability of this result is not assignable.

Description of key information

Triethoxy(phenyl)silane: 3.4 (QSAR)

Key value for chemical safety assessment

Log Kow (Log Pow):
3.4

Additional information

A log Kow value of 3.4 was obtained for the parent substance using an appropriate calculation method which is considered to be reliable. This value is supported by a measured log Kow value of 2.99 from secondary sources (handbook literature). The supporting result is in reasonable agreement with the key study.