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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion, other
Remarks:
in vivo study that was performed prior to current requirement for in vitro alternative testing
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report Date:
1985

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
guinea pig
Strain:
Hartley

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
24 hours
Observation period:
2 weeks
Number of animals:
five (5)

Results and discussion

In vivo

Results
Irritation parameter:
other: Observation
Score:
ca. 0
Max. score:
0
Remarks on result:
other: The was no numerical scoring used, but IUCLID TCC demands a value, so "0" was used as a placeholder.
Irritant / corrosive response data:
Slight or very slight edema was observed in one of 5 and 3 of 5 guinea pigs, respectively, at 24-48 hours after exposure to m-diisopropylbenzene. Edema was accompanied by moderate to severe erythema in 2 of 5 guinea pigs, and well-defined erythema in 2 of 5 guinea pigs. Moderate to severe erythema without edema was observed in one of 5 guinea pigs at 24-48 hours after exposure. For all test animals, there were no signs of edema or erythema at 2 weeks after exposure.

Any other information on results incl. tables

animal no. finding skin (post-exposure)
24-48 hrs 2 weeks
1 erythema mod-severe normal
edema normal
2 erythema well-defined normal
edema very slight normal
3 erythema mod-severe normal
edema very slight normal
4 erythema mod-severe normal
edema slight normal
5 erythema well-defined normal
edema very slight normal

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The test article, m-diisopropylbenzene, was determined to be slightly irritating
Executive summary:

Slight or very slight edema was observed in one of 5 and 3 of 5 guinea pigs, respectively, at 24-48 hours after exposure to m-diisopropylbenzene. Edema was accompanied by moderate to severe erythema in 2 of 5 guinea pigs, and well-defined erythema in 2 of 5 guinea pigs. Moderate to severe erythema without edema was observed in one of 5 guinea pigs at 24-48 hours after exposure. For all test animals, there were no signs of edema or erythema at 2 weeks after exposure. This compound was determined to be slightly irritating