Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report Date:
1985

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Rats were fasted overnight. Test article was administered neat via oral gavage
Doses:
1250, 2500, 5000 mg/kg
No. of animals per sex per dose:
five (5)
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
no deaths were observed in any treatment group
Clinical signs:
At most, slightly toxic orally. No compound-related effects were observed at gross pathology examination of the high-dose group of animals.
Body weight:
136-149 g (male); 143-160 (female)
Gross pathology:
No compound-related effects were observed at gross pathology examination of the high-dose group of animals.

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
No compound-related effects were observed at gross pathology examination of the high-dose group of animals. The compound (m-diisopropylbenzene) was considered to be slightly toxic following oral administration.
Executive summary:

No compound-related effects were observed at gross pathology examination of the high-dose group of animals. The compound (m-diisopropylbenzene) was considered to be slightly toxic following oral administration.