Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Medium:
other: sunflower oil
Remarks on result:
other: insoluble, particle disintegration observed under microscope
Medium:
other: silicone oil
Remarks on result:
other: insoluble, good dispersion
Medium:
other: kerosene
Remarks on result:
other: insoluble, but poor dispersion
Medium:
toluene
Remarks on result:
other: soluble
Conclusions:
D-lactide was found to be insoluble in kerosene, silicone oil and sunflower oils, but soluble in toluene.
Executive summary:

The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. D-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.

This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Medium:
other: sunflower oil
Solubility:
other: insoluble
Remarks on result:
other: insoluble, well dispersed
Medium:
other: silicone oil
Solubility:
other: insoluble
Remarks on result:
other: insoluble, well dispersed
Medium:
other: kerosene
Solubility:
other: insoluble
Remarks on result:
other: insoluble, but poor dispersion stability
Medium:
toluene
Solubility:
other: soluble
Conclusions:
In conclusion, it can be stated that L-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.
Executive summary:

The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. L-lactide is insoluble in kerosene, silicone oil and vegetable oil, but soluble in toluene.

This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).

Description of key information

The solubility of the test items in organic solvents was assessed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. L-lactide and D-lactide are insoluble in kerosene, silicone oil and vegetable oil, but soluble in toluene. L-lactide and D-lactide are suitable read across partners as dilactide is a mixture of D- and L-lactide isomers.

Key value for chemical safety assessment

Additional information