Registration Dossier
Registration Dossier
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EC number: 200-817-4 | CAS number: 74-87-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
skin and eye irritation:
Standard protocols for skin and eye irritation testing are not applicable to chloromethane as it exists as a gas.
Grant (1986) reported that exposure of a rabbit's eye to pure chloromethane gas at room temperature for ninety seconds causes only slight conjunctival hyperemia in two rabbits exposed for five days to concentrations from 250 to 465 ppm in air. There were no changes in the corneas, nor in pupillary reactions to light.
respiratory irritation:
In an acute inhalative toxicity test in rats no adverse effects were observed on the respiratory tract, which would justify a classification of chloromethane as an irritant to the respiratory tract (Griffiths and Watson, 2009).
Reference:
Grant, W.M. (1986). Toxicology of the eye. 3rd ed. Charles C Thomas, Springfield, pg. 613 [as cited in: OECD SIDS Chloromethane, 2004]
Justification for selection of skin irritation / corrosion endpoint:
Standard protocols for skin and eye irritation testing are not applicable to chloromethane as it exists as a gas.
Justification for selection of eye irritation endpoint:
Standard protocols for skin and eye irritation testing are not applicable to chloromethane as it exists as a gas.
Justification for classification or non-classification
eye irritation:
The available data is insufficient for classification according to DSD (67/548/EEC) and CLP (1272/2008/EC).
skin irritation:
There is no data available for classification or non-classification according to DSD (67/548/EEC) and CLP (1272/2008/EC).
respiratory irritation:
The available data is conclusive but nor sufficient for classification according to DSD (67/548/EEC) and CLP (1272/2008/EC).
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