2,2'-oxydiethanol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Secondary source; original study report not available.

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1970

Report date:

2001

Materials and methods

Principles of method if other than guideline:

The present primary skin Irritation study was conducted with 10 human volunteers (5 men, 5 women) to determine whether the test compound was irritating to human skin or not. The test was conducted according to Shelanski & Shelanski (Occluded Patch Test, 1953).

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-oxydiethanol

EC Number:

203-872-2

EC Name:

2,2'-oxydiethanol

Cas Number:

111-46-6

Molecular formula:

C4H10O3

IUPAC Name:

2-(2-hydroxyethoxy)ethan-1-ol

Details on test material:

purity: >96%; no further details provided.

Test animals

Species:

human

Test system

Type of coverage:

occlusive

Preparation of test site:

other: none

Vehicle:

unchanged (no vehicle)

Controls:

not required

Amount / concentration applied:

Three areas of 3 cm x 3 cm each, were selected on the skin of the left arm of each individual. 10 mg of the test substance was applied to each area as a finely ground powder. The powder was covered with a lintine disc and secured to the arm by sealing around the edges with Blenderm tape.

Duration of treatment / exposure:

After 2 hours, the cover of one contact area was removed from each subject, the powder was lightly brushed away, and the site examined for skin reactions.
After 4 hours, the second disk was removed and the skin examined.
After 6 hours, the third disk was removed and the skin examined.
All treatment sites were examined immediately after disk removal, and then again at 1, 4 and 24 hour intervals.

Number of animals:

Ten human volunteers (5 men, 5 women)

Results and discussion

In vivo

Results

Irritation parameter:

other: each application site was examined for skin reaction

Basis:

other: each volunteer

Reversibility:

fully reversible within: 24 h

Remarks on result:

other: One male subject exhibited slight erythema at 4 hours and marked erythema at 6 hours. One female subject exhibited slight erythema at 6 hours, and one female subject had marked erythema at 6 hours. All reactions disappeared in less than 24 hours.

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information

Conclusions:

The test compound was able to elicite very mild primary irritation effect on human skin which however was fully reversible within less than 24 hours.