Registration Dossier
Registration Dossier
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EC number: 203-872-2 | CAS number: 111-46-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability the test substance is acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 66 000 mg/L
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 75 222 mg/L
Additional information
Experimental data are available to determine acute toxicity of diethylene glycol to fish.
A short-term study using Pimephales promelas was performed. The 96 -h LC50 value was measured to be beyond 75222 mg/L (nominal, analytically verified, Geiger, 1995). Additionally, the study performed by PTAC (2006) is also available. The short-term test was performed with Oncorhynchus mykiss. The 96 -h LC50 was determined to be 66000 mg/L (nominal, analytically verified).
These results are supported with the estimated value, wich was derived from a valid QSAR model (ECOSAR v2.0; BASF SE, 2022). The 96 -h LC50 for the substance was predicted to be 327224 mg/L. The substance is within the applicability domain of the model.
Overall, it can be concluded that based on the available experimental and estimated data the substance is with high probability acutely not harmful to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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