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EC number: 614-725-0
CAS number: 68783-11-9
There are no toxicokinetic studies of gasoline or naphthas, per se. However, assessments of gasoline constituents can be used as the basis for understanding the toxicokinetics of gasoline or naphthas as complex substances.
There are no experimental studies of the
toxicokinetics of gasoline per se, but there have been numerous
toxicokinetic studies of the major gasoline constituents. The
principal route of exposure for most individuals is inhalation. It
has been shown that absorption of inhaled constituents increases with
increasing molecular weight, with n-paraffins being more highly absorbed
than iso-paraffins and aromatics being more highly absorbed than the
corresponding paraffins. The
low molecular weight constituents (butanes and pentanes) are poorly
absorbed and predominantly exhaled unchanged. The
higher molecular weight constituents are more efficiently absorbed, with
metabolism, normally to the corresponding alcohols, and excretion in the
urine becoming increasingly important. About 15% of the butanes and
pentanes are absorbed with biological half-times measured in minutes. About
25% of the hexanes and 50% of the higher molecular weight constituents
are absorbed with biological half-times ranging from approximately 3-12
hours depending on whether the assessment is based on blood or urinary
Dermal contact normally contributes
little to overall dose as gasoline constituents in the vapor phase are
poorly absorbed percutaneously. Studies
with toluene indicate that dermal absorption from vapor is approximately
1% of the amount absorbed by inhalation. When
contacted as liquid, gasoline constituents are also poorly absorbed if
allowed to evaporate. However,
if evaporation is impeded then the fraction absorbed can be substantial. Other
toxicokinetic properties of percutaneously absorbed gasoline
constituents are similar to material absorbed by inhalation.
Oral ingestion also normally contributes
little to overall dose as gasoline is not intended for consumption. However,
most of the constituents are well absorbed from the gastrointestinal
assumption of 100% bioavailability of ingested material is reasonable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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