Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Data waiving:
other justification
Justification for data waiving:
other:

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Details on test material:
Physical form of substance: L
Mass median aerodynamic diameter (for liq.+solid aerosol):
2.11um

Test animals

Species:
other: Rat (Sprague-Dawley)

Administration / exposure

Vehicle:
other: None
Details on inhalation exposure:
Nose only
Duration of exposure:
4 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 5.13 mg/L air
Exp. duration:
4 h
Mortality:
Male: 5.13 mg/L; Number of animals: 5; Number of deaths: 1
Female: 5.13 mg/L; Number of animals: 5; Number of deaths: 1
Clinical signs:
other: Signs of toxicity related to dose levels: During exposure, decreased respiratory rate was noted in all animals and there were occasional instances of laboured respiration. On removal from the chamber, animals showed decreased respiratory rate and ther
Gross pathology:
Effects on organs:
The lungs of the two animals that died during the study were
found to be filled with fluid and pale or abnormally dark
or with dark patches.

No macroscopic abnormalities were detected in the animals
that survived until the study ended.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified in accordance with EU criteria