Registration Dossier
Registration Dossier
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EC number: 418-140-1 | CAS number: 5117-12-4 ACRYLOYLMORPHOLIN
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Basierend auf der Vorschrift der Kommission Fur Product-sicherheit fur den Verbraucher der Vereinigten Staaten von Amerika (Federal Regulation(CFR),par.16,Absaiz 15.41)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-(1-oxo-2-propenyl)-morpholine
- EC Number:
- 418-140-1
- EC Name:
- 4-(1-oxo-2-propenyl)-morpholine
- Cas Number:
- 5117-12-4
- Molecular formula:
- C7H11NO2
- IUPAC Name:
- 4-(1-oxo-2-propenyl)-morpholine
Constituent 1
Test animals
- Species:
- other: rbt.Weibe Neuseelander
Test system
- Type of coverage:
- occlusive
- Vehicle:
- other: none
- Duration of treatment / exposure:
- 24h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Score:
- 0.5
- Max. score:
- 1
- Remarks on result:
- other: Max duration: 3d; Max.Value at end of observation period:0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Max. duration:0d; Max.value at end of observation period:0
- Irritant / corrosive response data:
- Reversibility of any observaion effect: Changes fully reversible within 3 days.
- Other effects:
- Results in the table refer to the intact skin.
The abraded sdkin was observed at the same time. The average for erythemae was 0.8 and for edemae0.
The max.Value for arythema was 1 and for edema 0. The max.
Duration was < 3 days.
The maximal values at the end of the study: 0.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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