Registration Dossier
Registration Dossier
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EC number: 231-765-0 | CAS number: 7722-84-1
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: (a) male reproductive toxicity; (b) estimation of peroxide breakdown by rabbit semen in vitro
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- publication
- Title:
- The spermicidal activity of hydrogen peroxide in vitro and in vivo
- Author:
- Wales RG, White IG and Lamond DR
- Year:
- 1 959
- Bibliographic source:
- J Endocrin 18, 236-244
Materials and methods
- Principles of method if other than guideline:
- Method: other: see below
- GLP compliance:
- no
Test material
- Reference substance name:
- Hydrogen peroxide
- EC Number:
- 231-765-0
- EC Name:
- Hydrogen peroxide
- Cas Number:
- 7722-84-1
- Molecular formula:
- H2O2
- IUPAC Name:
- hydrogen peroxide
- Details on test material:
- IUCLID4 Test substance: other TS: hydrogen peroxide, 30%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- other: (a) oral, drinking water; (b) in vitro
- Duration of treatment / exposure:
- Exposure period: (a) 6 weeks
Duration of test: (a) 6 weeks - Frequency of treatment:
- (a) daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.33, 1 or 3% hydrogen peroxide solution; 3 rabbits per group
Basis:
- Control animals:
- no
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
There were no detectable abnormalities in the sperm of the
three rabbits exposed for 6 weeks. The mean amount of
hydrogen peroxide broken down by 1 mL rabbit seminal plasma
when mixed with 0.01M H2O2 at 0oC for 3 min was 220 mg
(range 95-353 for eight ejaculates) The results for rabbit
spermatozoa were also variable: the mean mass weight of
hydrogen peroxide decomposed by 109 cells in 3 min was 81 mg
(range 40-153 for 6 ejaculates). As rabbit semen had proven
more resistant to hydrogen peroxide than semen from other
species, ram seminal plasma, dog sperm-fraction plasma and
dog prostatic fluid were studied for their capacity to
decompose peroxide. The first two had some but low
activity, dog prostatic fluid was completely inert.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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