Registration Dossier
Registration Dossier
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EC number: 231-765-0 | CAS number: 7722-84-1
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Adequacy of study:
- supporting study
Data source
Reference
- Title:
- No information
- Author:
- Kondrashov, V.A.: Evaluation of the toxicity of hydrogen|peroxide vapors for inhalation and percutaneous exposures.|Gig Tr Prof Zabol 1977;21(10):22-25. [Russian, English|translation]
Materials and methods
- Principles of method if other than guideline:
- Method: other: Subchronic study (4 months, 5 h per day, 5 d a week) using combined inhalation and dermal (hair was clipped) exposure were conducted with rats. Exposures to H2O2 vapours were conducted on 874 white rats weighing 150-250 g.
- GLP compliance:
- no
Test material
- Reference substance name:
- Hydrogen peroxide
- EC Number:
- 231-765-0
- EC Name:
- Hydrogen peroxide
- Cas Number:
- 7722-84-1
- Molecular formula:
- H2O2
- IUPAC Name:
- hydrogen peroxide
- Details on test material:
- IUCLID4 Test substance: other TS: hydrogen peroxide, no further detail
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: inhalation (and dermal)
- Duration of treatment / exposure:
- 2-4 months
- Frequency of treatment:
- 5 h per day, 5 d per week up to 4 months
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 - 10.1 mg/m3 (vapour)
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: not given
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Effects: The threshold concentration of H2O2 vapours for the respiratory organs was shown to be 10 mg/m3, the no-effect concentration was 1 mg/m3. At two and three months of exposure to 10 mg/m3 an increase was noted in the serum epoxidase activity (2.50 and 2.63, respectively, in the control animals 2.16 and 2.20). After 4 months the lungs showed a decrease of succinate dehydrogenase activity (SDH) (0.26 among exposed animals versus 0.34 in controls). After 4 months, histoenzymological studies of the lungs revealed a decrease in the activities of SDH, monoamine oxidase (MAO), acid phosphatase, diesterase, and an increase in the activity of alkaline phosphatase.
Applicant's summary and conclusion
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