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EC number: 231-765-0 | CAS number: 7722-84-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
A valid guideline study on the inhibition of the activity of microorganisms by hydrogen peroxide exposure is available, which resulted in a EC50 value of 466 mg/L.
Key value for chemical safety assessment
Additional information
A valid respiration inhibition test using activated sludge from a primarily domestic wastewater treatment plant was carried out with hydrogen peroxide according to OECD Guideline No. 209 and to GLP. Concentrations of hydrogen peroxide were tested over the range of 1 to 1000 mg/L. Two controls with no exposure to hydrogen peroxide were included. Test solutions were incubated for 30 minutes or 3 hours, before the oxygen demand was measured once per minute during a period of 11 minutes. Hydrogen peroxide inhibited the respiration of activated sludge in a concentration dependent manner. However, the effect was reversible with time due to the rapid degradation of hydrogen peroxide mediated by the biological matrix. The EC50 value determined for the test solution incubated for 30 minutes was 466 mg/L, whereas the EC50 value determined for the test solution incubated for 3 hours was greater than 1000 mg/L.
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