Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2003
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented company data which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

GLP compliance:
yes
Test type:
acute toxic class method

Test material

Constituent 1
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Chemical identifier paramaters as defined in section 1.1 and 1.2.
Batch: 021302

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water

Results and discussion

Any other information on results incl. tables

The test substance toxicity was evaluated on the basis of mortality, clinical signs of intoxication, body weight increments during the observation period and necropsy findings in the end of study.

The test substance in the dose 2000mg/kg caused death of 2 laboratory animals, clinical signs of intoxication were observed in all animals, macroscopic changes were diagnosed in pathological examination of all animals (also in survived animals). Digestive system was highly affected (stomach, small intestine and liver). In all animals also changes in lung were diagnosed ( oedema and haemmorrhages).

The test substance in the dose level 200mg/kg caused death of no animals.

Applicant's summary and conclusion

Conclusions:
The value of the LD50 for rats of both sexes of the test substance, is situated within the interval of vales 200 mg/kg to 2000mg/kg of body
weight. The test substance is classifed as harmful.
Executive summary:

The test substance is classified as harmful.