Registration Dossier
Registration Dossier
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EC number: 415-950-5 | CAS number: 155522-14-8
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The hydrolysis reaction at pH 7.0 and a temperature of 25°C is very fast with a hydrolysis half-life of < 1 day.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 d
- at the temperature of:
- 25 °C
Additional information
A hydrolysis test was performed following the OECD 111 guideline and EEC C7 guideline under GLP. The hydrolysis of the test article was performed at 50 °C ± 0.1 °C at each of pH 4.0, pH 7.0, and pH 9.0.
The percentage of hydrolysis at pH 4.0 was found to be more than 10% after 5 days. Therefore, according to the guidelines advanced testing of the test substance was performed to determine the rate constant (k25) of the hydrolysis reaction at pH 4.0.
The percentage of the hydrolysis at pH 7.0 and pH 9.0 was found to be more than 50% after 2.4 hours incubation at 50 °C ± 0.1 °C. Therefore, according to the guidelines no further testing was performed at pH 7.0 and pH 9.0. The hydrolysis reaction at pH 4.0 and 25 °C was estimated to be relative slow (t1/2 at 25 °C = 50.3 days). The hydrolysis reactions at 25 °C and at pH 7.0 and pH 9.0, respectively were evaluated to be very fast (t1/2 at 25 °C < 1 day). The activation energy at pH4.0 was estimated to be 75.8 kJ/mol and the reaction rate constant (k25) pH4 .0 was estimated to be 5.74E-04/h.
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