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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 March 2015-19 June 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-compliant study in accordance with EC A.6, OECD 105 and OPPTS 830.7840.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
(2008)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
(1995)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
(1998)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
3-[3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)propoxy]propane-1,2-diol
EC Number:
807-413-2
Cas Number:
70280-68-1
Molecular formula:
C13H34O5Si3
IUPAC Name:
3-[3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)propoxy]propane-1,2-diol
Test material form:
other: Liquid
Details on test material:
- Name (as cited in study report): X-22-1927
- Appearance: clear light yellow liquid
- Storage conditions: at room temperature

Results and discussion

Water solubility
Water solubility:
0.013 g/L
Temp.:
20 °C
pH:
6.9 - 7.1
Remarks on result:
other: Mean of the concentrations analysed at t=24, 48 and 72 h.
Details on results:
The concentration analysed after 24, 48 and 72 hours of stirring was 0.0128 g/L, 0.0123 g/L and 0.0145 g/L , resp. The maximum difference is slightly above 15% (i.e. 16%). Since the deviation is small and no trend was observed, this deviation was accepted and the water solubility was calculated as the mean of all 3 measurements.

No test substance was detected in the pretreated sample from the blank water mixture.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
In a GLP-compliant study in accordance with EC A.6, OECD 105 and OPPTS 830.7840 using the flask method, the water solubility of the substance at 20°C and pH 6.9-7.1 has been determined as 0.013 g/L.