Registration Dossier
Registration Dossier
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EC number: 431-850-4 | CAS number: 7456-68-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.2; OECD 403
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
1.95 µm
Constituent 1
Test animals
- Species:
- other: rat, Fischer 344
Administration / exposure
- Details on inhalation exposure:
- nose-only
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.22 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: .22 mg/L; Number of animals: 5; Number of deaths: 0
Female: .22 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Behandlungsabhängige Effekte welche sich im Ausfluss von Urin oder Kot wie auch in der Verfärbung des Urins äußerten. Diese Befunde traten nach dem Tage 4 nicht mehr auf. 10 Tiere/Geschlecht zeigten nach der
- Gross pathology:
- Effects on organs:
In den Lungen von 2/5 Tieren/Geschlecht, welche 4 Stunden
ausgesetzt waren und am Tage 2 getötet wurden, traten keine
Punkte von alveolaren Makrophagen oder Blutungen auf. Diese
Befunde waren nicht eindeutig, da unbehandelte Tiere die
selben Befunde aufwiesen. Alle andere Beobachtungen sind
vernachlässigbar und bei einer solchen Änderung der Umgebung
für Ratten von diesem Stamm und diesem Alter zu erwarten.
"ENGLISH"
Small foci of alveolar macrophages or hemorrhage were
present in the lungsof two of 5 rats/sex from those
necropsied the day following the single four-hour exposure
(test day 2). The relationship of these lesions to exposure
is equivocal because similar lesions may be found in
unexposed rats. All other observations were of minimal
degree and were considered typical of spontaneous changes
expected for rats of this strain, age and husbandry
conditions.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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