Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 92/69/EWG, C.1; OECD 203 (1992)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Details on test solutions:
TS showed a hydrolysis rate of less than 2.4 hours at pH 9 and 50°C. A structural analysis indicates that the test item is highly reactive and could form multiple
oxidation products. It was determined that a semi-static test should be conducted to include degradation products. As such, the test solutions were prepared 48 hours prior to the introduction of the test species and the test species were transferred to new test solutions (prepared 48 hours prior to use) every 24 hours. HPLC analysis of the test solutions indicated that the pattern of formation of the degradation products at the start of the test and at the end of the test was almost similar. As the measured concentrations of the test item in some of the groups was below the limit of quantification (LOQ = 10 ng/mL) and the concentration of the degradation products was not known, all results are reported based on the nominal concentrations of the test item.

Test organisms

Test organisms (species):
other: Brachydanio rerio (Zebrabärbling)

Study design

Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
11.59 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality

Applicant's summary and conclusion