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EC number: 231-984-1 | CAS number: 7783-20-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Toxicological Summary
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- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- A case of fatal intoxication with ammonium sulfate and a toxicological study using rabbits.
- Author:
- Sato A et al.
- Year:
- 1 999
- Bibliographic source:
- Forensic Science International101: 141-149.
Materials and methods
- Objective of study:
- distribution
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ammonium sulphate
- EC Number:
- 231-984-1
- EC Name:
- Ammonium sulphate
- Cas Number:
- 7783-20-2
- Molecular formula:
- H3N.1/2H2O4S
- IUPAC Name:
- diammonium sulfate
- Test material form:
- solid: crystalline
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- other: Japanese white
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Japanese white rabbits
- Weight at study initiation: 3.4 - 3.8 kg
no further data
ENVIRONMENTAL CONDITIONS: no data
Administration / exposure
- Route of administration:
- other: gastric tube
- Vehicle:
- physiological saline
- Duration and frequency of treatment / exposure:
- single dose
Doses / concentrations
- Dose / conc.:
- 1 500 other: mg/kg/bw
- No. of animals per sex per dose / concentration:
- 3 (test group);
2 (control group) - Control animals:
- yes, concurrent vehicle
- Positive control reference chemical:
- no
Results and discussion
Any other information on results incl. tables
General findings
The three rabbits used in this experiment showed similar symptoms. Mydriasis and slight irregular respiratory rhythms appeared at 10 to 20 min after ingestion of the ammonium sulfate solution. Local convulsions persisting for 5 to 10 min in the face or in the extremities starting 15 to 25 min after ingestion and soon after it spread to every part of the body, at which time they exhibited opisthotonus lasting for 1 0 to 20 s which repeated itself several times.
After the general convulsions, heart rates decreased suddenly (N=1) or gradually (N=2) depending on the rabbit and the pneumonic respiration became quiet and weak. In 60 to 70 min after the ingestion, all the rabbits fell into breathlessness along with cardiac arrest.
Blood examination
Blood gas analysis:
The value of pH, HCO3 and Base Excess decreased promptly. On the other hand, PO2 and PCO2 did not show remarkable changes during the experiment until the animals died. These results show that severe metabolic acidosis developed after ingestion of the test substance.
Ammonium and sulfate ion concentration:
The concentration of ammonium in serum had already increased remarkably 5 min after ingestion (1095 +/- 535 µg/dl , mean +/- SD), until it reached 11000 +/- 1200 µg/dl after 60 min
Inorganic sulfate ion concentration started to increase at 10 min after ingestion and its level continued to increase linearly to 20 +/- 4.9 mEq/l after 60 min
Biochemical analysis:
Electrolytes of Na+, K+, Cl - and Ca2 + did not show any significant change during the experiment except for a moderate increase in K+ just before cardiac arrest. Concentration of released enzymes such as AST, ALT and LDH remained constant and normal levels were maintained throughout the experiment. Also, the values of BUN and creatinine were always within a normal range.
Histological observation
Brain, heart, lung, spleen, kidney, liver and stomach were observed microscopically, but no pathological changes such as hemorrhage, degeneration or necrosis of tissue were found.
In control group of rabbit ingesting saline, there was no significant finding on physiological monitoring, blood examination, histological observation.
Applicant's summary and conclusion
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