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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Remarks:
other: not specified
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: According to the OECD SIDS document for sodium hydroxide (March 2002), a Klimisch 4 reliability score was assigned since the original reference is not available.

Data source

Reference
Reference Type:
publication
Title:
No title available
Author:
Dluhos et al.
Year:
1969
Bibliographic source:
cited in: Martin FM, Report EPA/600/8-88/081, Order-No. PB88-231949, 1988

Materials and methods

Principles of method if other than guideline:
other: not specified
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hydroxide
EC Number:
215-185-5
EC Name:
Sodium hydroxide
Cas Number:
1310-73-2
Molecular formula:
HNaO
IUPAC Name:
sodium hydroxide
Details on test material:
- Name of test material (as cited in study report): sodium hydroxide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
10 weeks
Frequency of treatment:
20 min., twice weekly
Doses / concentrations
Remarks:
Doses / Concentrations:
40% (dispersed aerosol)
Basis:

Control animals:
other: no data specified
Details on study design:
Post-exposure period: not specified

Results and discussion

Results of examinations

Details on results:
Bronchial epithelium was sometimes wrinkeled, sometimes flattened and in places ulcerated and necrotic; the peribronchial lymphadenoid tissue was hypertrophic and extruded cushion-like into the bronchial lumen, causing slit-like deformities.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion