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The introductory sections to Annexes VII-X point at a specific adaptation to the standard information requirements as in vivo testing shall be avoided with corrosive substances at concentration/dose levels causing corrosivity. However, NaOH is not expected to be systemically available in the body under normal handling and use conditions and therefore systemic effects of NaOH after repeated exposure are not expected to occur (EU RAR of sodium hydroxide (2007); section, page 76).

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