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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
other: Data sharing dispute
Adequacy of study:
key study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: According to the OECD SIDS document for sodium hydroxide (March 2002), a Klimisch 3 reliability score was assigned since the documentation is insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Hydrotherapy of Chemical Burns
Author:
Bromberg et al.
Year:
1965
Bibliographic source:
Plast Reconstr Surg 35, 85-95

Materials and methods

Principles of method if other than guideline:
Sodium hydroxide was applied to the back of 27 mice. Afterwards the area was irrigated for 1 hour with water at various time intervals.
GLP compliance:
no
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hydroxide
EC Number:
215-185-5
EC Name:
Sodium hydroxide
Cas Number:
1310-73-2
Molecular formula:
HNaO
IUPAC Name:
sodium hydroxide
Details on test material:
no data

Test animals

Species:
mouse
Strain:
other: 54 A/He and C57 black adult mice
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: not described
- Age at study initiation: adult
- Weight at study initiation: 25-35 g

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Details on dermal exposure:
TEST SITE
- Area of exposure: circular 2 cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): Afterwards the area was irrigated for 1 hour with water at various time intervals
- Time after start of exposure: no data

TEST MATERIAL
- Concentration (if solution): 50% NaOH
No. of animals per sex per dose:
27
Control animals:
not specified

Results and discussion

Effect levels
Remarks on result:
other: no details reported
Mortality:
The mortality of the mice was 0; 20; 40; 80 and 71 % when they were irrigated immediately, 30 minutes, 1 hour, 2 hours or not at all after the application.

Applicant's summary and conclusion