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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: According to the OECD SIDS document for sodium hydroxide (March 2002), a Klimisch 3 reliability score was assigned since documentation is insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
No title available
Author:
Naunyn-Schmiedeberg's
Year:
1937
Bibliographic source:
Archiv für experimentielle Pathologie und Pharmakologie (Berlin, Germany), 184, 587-604

Materials and methods

Principles of method if other than guideline:
other (not specified)
GLP compliance:
no
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hydroxide
EC Number:
215-185-5
EC Name:
Sodium hydroxide
Cas Number:
1310-73-2
Molecular formula:
HNaO
IUPAC Name:
sodium hydroxide
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 2500-3500 g

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 160-940 mg/kg bw
MAXIMUM DOSE VOLUME APPLIED: 4.9-31 ml/kg body weight

No. of animals per sex per dose:
46 animals (no data for sex)
Control animals:
not specified
Statistics:
not described

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
325 mg/kg bw

Applicant's summary and conclusion