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additional toxicological information
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Cardiorespiratory changes following chemical applications to gut serosa.
Author:
Radhakrishnan et al
Year:
1985
Bibliographic source:
J Auton Nerv Syst, 14(4):363-75

Materials and methods

Type of study / information:
other

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hydroxide
EC Number:
215-185-5
EC Name:
Sodium hydroxide
Cas Number:
1310-73-2
Molecular formula:
HNaO
IUPAC Name:
sodium hydroxide

Results and discussion

Any other information on results incl. tables

Application of 0.2-0.3 ml of 0.5% sodium hydroxide to gastrointestinal serosa produced a fall in blood pressure and inhibition of respiration in hypertensive as well as normotensive rats. In 6 (8%) of the animals studied, a fall in heart rate was also seen which was blocked by atropine.

Applicant's summary and conclusion