Registration Dossier
Registration Dossier
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EC number: 202-851-5 | CAS number: 100-42-5
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication meeting basic scientific principles.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Human exposure to styrene. IV Percutaneous absorption in human volunteers.
- Author:
- Berode, M. et al.
- Year:
- 1 985
- Bibliographic source:
- Int Arch Occup Environ Health 55: 331-336
- Reference Type:
- review article or handbook
- Title:
- European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
- Author:
- European Union
- Year:
- 2 007
- Bibliographic source:
- Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Nine male volunteers were exposed for 10 to 30 min by dipping one hand in liquid styrene.
- GLP compliance:
- no
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): liquid styrene
- Physical state: liquid
- Analytical purity: no data
Method
- Type of population:
- general
- Subjects:
- Volunteers chosen from the Institute of Occupational Medicine and Industrial Hygiene of the University of Lausanne, Switzerland.
- Ethical approval:
- not specified
- Route of exposure:
- other: full hand dipping
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Medical treatment:
- No treatment
Results and discussion
- Clinical signs:
- There was no mention of any signs of skin irritation in this study of 9 volunteers dipping one hand fully into liquid styrene for up to 30 minutes.
- Results of examinations:
- There was no mention of any signs of skin irritation in this study of 9 volunteers dipping one hand fully into liquid styrene for up to 30 minutes.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
