Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

No data are available: a waiver is proposed. Anhydrous ammonia is listed on Annex I of Directive 67/548/EEC with classification as (R34) 'Causes burns'. Testing for skin sensitisation is not justified on scientific grounds or for reasons of animal welfare. The local dermal effects of the substance will be dominated by irritation/corrosion and sensitisation is considered to be unlikely.


Migrated from Short description of key information:
No data are available. The local dermal effects of anhydrous ammonia will be dominated by irritation/corrosion and sensitisation is considered to be unlikely.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

It is considered unlikely that ammonia is a respiratory sensitiser. The local respiratory tract effects of the substance will be dominated by irritation. There are no reports of occupational asthma attributable to ammonia exposure. Ammonia is exhaled in small quantities as a consequence of its presence in the blood from protein catabolism.


Migrated from Short description of key information:
No data are available

Justification for classification or non-classification

There is no evidence that ammonia causes skin or respiratory tract sensitisation. No classification is proposed.