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Administrative data

Description of key information

A non-standard study in the rat indicates that exposure to anhydrous ammonia causes skin burns.  No data are available for eye irritation, however it is assumed that the substance is a severe irritant.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Anhydrous ammonia is listed on Annex I of Directive 67/548/EEC with classification as (R34) 'Causes burns', therefore waivers are acceptable for skin and eye irritation. Nevertheless, the available data are reported.

Skin irritation

Prokop'eva et al (1973) report skin burns in rats exposed to anhydrous ammonia. Vernot et al (1977) report corrosive effects for a 12% aqueous solution but not for a 10% aqueous solution.

Eye irritation

No information is available, however can be assumed that the substance causes severe eye irritation,

Respiratory irritation

Animal data and human reports indicate that the substance is a respiratory irritant.


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Anhydrous ammonia is listed on Annex I of Directive 67/548/EEC with classification as (R34) 'Causes burns'. This classification is consistent with the data available. No change to this classification is proposed.