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Toxicological information

Carcinogenicity

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Description of key information

The data set compiles 3 studies on different forms of SAS substance (BET range from 90 to 350 m³/g) in animals. 2 Studies conducted in 1988 according to OECD guideline 453 (Klimisch score 2) did not show evidence of significant carcinogenicity after chronic oral application to both rats and mice. No alteration in survival rate, bodyweight, food consumption, behaviour, organ weights or blood chemistry were observed. Gross or microscopic changes or neoplasms were not detected in any of the examined tissues. The NOEL for rats and mice was determined as 5% in the diet.

Additionally, a surface treated SAS was tested at a dose of 100 mg/kg bw/day applied over a period of 24 months to rats. This material also did not show any carcinogenic potential after oral administration.

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Additional information

Justification for classification or non-classification

Three available studies did not evidence any carcinogenic potential. According to Annex I of the Regulation (EC) 1272/2008 and GHS (Globally Harmonized Classification System), the test substance therefore requires no classification and has no mandatory label requirement.