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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: review - expertise - secondary source

Data source

Reference
Reference Type:
review article or handbook
Title:
Gesundheitsschaedliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begruendung von MAK-Werten (Maximale Arbeitsplatz-Konzentrationen). Amorphe Kieselsaeuren
Author:
MAK (Kommission zur Pruefung gesundheitsschaedlicher Arbeitsstoffe der Deutschen Forschungsgemeinschaft)
Year:
1994
Bibliographic source:
VCH Verlagsgesellschaft mbH, Weinheim
Report Date:
1989

Materials and methods

Type of study / information:
occupational exposure concentrations (monitoring)
Endpoint addressed:
not applicable
Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
FK 700, 86.65 % SiO2, 7.3 % hydration water (SiO2): Silica, precipitated, crystalline-free, CAS No.: 112926-00-8:Specific surface area (BET) = 700 m2/g

Method

Exposure assessment:
measured
Details on exposure:
TYPE OF EXPOSURE: Inhalation


TYPE OF EXPOSURE MEASUREMENT: Area air sampling


EXPOSURE LEVELS: below MAK value


EXPOSURE PERIOD: =< work shift


DESCRIPTION / DELINEATION OF EXPOSURE GROUPS / CATEGORIES: no details

Results and discussion

Any other information on results incl. tables

Measurements that were conducted in the silica-producing or processing industry (Germany) during 1984 and 1986 resulted in average values of 2.2 and 4.4 mg/m3 of inhalable dust, the values of respirable dust during simultaneous determination (27 measurements) ranged between 0.7 and 1.7 mg/m3.

During industrial processing of amorphous silicas in various companies in the 1980th (Germany), concentrations of respirable dust ranged from 0.04 to 1.9 mg/m3 with an average of 0.46 mg/m3 (56 measurements). These findings included general dust that may have been unrelated to the specific process.

Applicant's summary and conclusion