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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Information extracted from acetic acid EU DAR acetic acid, 2008, under Dir 91/414/EEC
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: list IV.
Author:
Smyth HF, Carpenter CP & Weil CS
Year:
1951
Bibliographic source:
Arch Ind. Hyg. vol 4, pp 119-122

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A group of 6 rats was exposed to a concentration of 16,000 ppm acetic acid for 4 hours and was then observed for up to 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetic acid
EC Number:
200-580-7
EC Name:
Acetic acid
Cas Number:
64-19-7
Molecular formula:
C2H4O2
IUPAC Name:
acetic acid
Details on test material:
- Name of test material (as cited in study report): Acetic acid
- No further details

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
clean air
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
16000 ppm (39360 mg/m3)
No. of animals per sex per dose:
6 (sex not reported)
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 16 000 ppm
Exp. duration:
4 h
Remarks on result:
other: 40,000 mg/m3; 1 out of 6 rats died
Mortality:
1 out of 6 rats exposed to 16000 ppm (40,000 mg/m3) died within 14 days of exposure. No other details reported.
Clinical signs:
other: Not reported

Applicant's summary and conclusion

Conclusions:
The acute inhalation toxicity of acetic acid in the rat, following a 4 hour exposure, was > 16000ppm, equivalent to > 40 mg/L
Executive summary:

A group of 6 rats was exposed to a concentration of 16,000 ppm acetic acid for 4 hours and was then observed for up to 14 days. One out of 6 rats died within 14 days of exposure. The acute inhalation toxicity of acetic acid in the rat, following a 4 hour exposure, was > 16000ppm, equivalent to > 40, 000 mg/m3.