Registration Dossier

Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: English summary only. Information extracted from acetic acid DAR under Dir 91/414/EEC
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Pathology due to acetic acid: observations on experimental animals and men.
Author:
Ghiringhelli L & Di Fabio A
Year:
1957
Bibliographic source:
Med Lavoro, vol 48, pp559-565

Materials and methods

Study type:
other: no details reported
Endpoint addressed:
skin irritation / corrosion
eye irritation
respiratory irritation
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A group of 12 workers emploed for 2-19 years in a cellulose acetate factory were observed for irritative symptoms in skin, eyes and respiratory tract.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetic acid
EC Number:
200-580-7
EC Name:
Acetic acid
Cas Number:
64-19-7
Molecular formula:
C2H4O2
IUPAC Name:
acetic acid
Details on test material:
- Name of test material (as cited in study report): Acetic acid
- Other: No further details reported

Method

Type of population:
occupational
Ethical approval:
not specified
Details on study design:
A group of 12 workers employed for 2-19 years in a cellulose acetate factory were observed for irritative symptoms in skin, eyes and respiratory tract. The average concentration of acetic acid vapour in the air was 0.125 mg/L but could increase to an average of 0.44 mg/L during certain work phases.

Results and discussion

Results:
Irritative symptoms of the conjunctiva and upper respiratory tract were observed in 8 individuals.
Erosion of the incisors was noted in 5 workers.
All workers had palmar skin that was dry, thickened and blackened with rhagadiform lesions. (taken from EU DAR acetic acid, 2008).

Applicant's summary and conclusion

Conclusions:
Long term exposure to concentrations of acetic acid vapour (average 0.125 mg/L with peaks of up to 0.44 mg/L) was associated with hyperkeratotic dermatitis with rhagdiform lesions of the palmar skin of the hands and respiratory and conjunctival irritation.
Executive summary:

In a group of 12 workers employed for 2 years of more in a factory where the average concentration of acetic acid vapour was 0.125 mg/L (with peaks of up to 0.44 mg/L during certain work phases), hyperkeratotic dermatitis with rhagdiform lesions of the palmar skin of the hands was present in all workers while respiratory and conjunctival irritation.was present in 8. Five workers also had some erosion on their incisors.