Registration Dossier

Administrative data

Description of key information

Acetic acid is concluded to produce no signs of neurotoxicity.

Key value for chemical safety assessment

Additional information

Acetic acid, as an active substance, has been considered under the fourth stage of the re-evaluation programme of the Plant Protection Product Directive 91/414/EEC (provisions of Regulation (EC) No 1112/2002) for use as a herbicide on e.g. pome and stonefruit, ornamental shrubs, paths. The decision has been made that it is included in Annex I of that Directive (Commission Directive 2008/127/EC of 18 December 2008 amending Council Directive 91/414/EEC to include several active substances) and therefore the use of acetic acid as a Plant Protection Product it is therefore regarded as registered under REACh (Article 15 of EC Reg 1907/2006). The toxicology endpoints addressed under Dir. 91/414/EEC to conclude on toxicological hazard are directly comparable with those under REACh.

EFSA supported the recommendations by the rapporteur Member State and the result of the examination in accordance with the provisions of Article 24a of Regulation 2229/2004 stating that there are clear indications that it may be expected that this use of acetic acid does not result in any harmful effects on human health (EFSA, 2013). The Draft Assessment Report (EU DAR, 2008) states that “Acetic acid is a food ingredient and food additive which does not produce signs of neurotoxicity after ingestion at quantities relevant for human consumption. Testing by oral route is therefore not required."

Citation:

EFSA (2013): Conclusion on the peer review of the pesticide risk assessment of the active substance acetic acid; EFSA Journal 2013;11(1):3060

Justification for classification or non-classification

Since there is no evidence of neurotoxicity, no classification is warranted under DSD or CLP.