Registration Dossier

Administrative data

Endpoint:
pH
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP status not known, information from published handbook, acceptable with restrictions

Data source

Reference
Reference Type:
review article or handbook
Title:
Merck Index Encyclopedia of chemicals, drugs and biologicals; 14th ed.
Author:
O'Neil, M.J. (Ed.)
Year:
2006
Bibliographic source:
Merck & Co., Inc. Whitehouse Station, NJ

Materials and methods

Principles of method if other than guideline:
The use of secondary sources of data is acceptable when they are based on a critical evaluation of peer-reviewed data and a consequent selection of a reliable and representative value for the property under investigation. The introduction to the Merck Index states that physical data are cited as found in the literature. When several alternate data values appear in the literature, the data is evaluated and representative selections are made; values are then reported with the corresponding source. Therefore, although the method used is not known, the values presented here are acceptable as they are from a reliable secondary source of phys chem. data.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetic acid
EC Number:
200-580-7
EC Name:
Acetic acid
Cas Number:
64-19-7
Molecular formula:
C2H4O2
IUPAC Name:
acetic acid
Details on test material:
No data reported

Results and discussion

pH valueopen allclose all
pH value:
2.4
Remarks on result:
other: 1 M
pH value:
2.9
Remarks on result:
other: 0.1 M
pH value:
3.4
Remarks on result:
other: 0.01 M

Any other information on results incl. tables

No further information provided

Applicant's summary and conclusion

Conclusions:
The pH values for acetic acid are as follows: 1.0M =2.4, 0.1M = 2.9, 0.01M = 3.4
Executive summary:

No information on the primary source of this data or the methods used is available. However, this information is taken from a reliable peer reviewed handbook and so can be considered reliable and suitable for use as the key study for this endpoint.