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EC number: 912-631-7
CAS number: 12022-95-6
All acute inhalation studies performed with dry dust were hampered by
the technical problem to achieve the recommended highest test
concentration of 5 mg/l, apparently attributable to the high adhesive
forces which caused rapid precipitation onto equipment walls. Therefore,
the maximum attainable chamber concentrations were distinctly lower than
The OECD (2004) reviewed that there was no lethal effects
following inhalation exposure of rats to the highest technically
feasible concentrations of 140 to 2,000 mg/m3 of hydrophilic
precipitated or pyrogenic silica. However, the acute inhalation of
synthetic amorphous silica dust may cause discomfort and stress as well
as signs of local irritation to the nasal, bronchiolar and ocular mucous
membranes. In conclusion, the synthetic amorphous silica dust is
considered to be acutely non-toxic via an inhalation route.
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