Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-111-4 | CAS number: 7440-02-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Value used for CSA:
NOAEL (oral, systemic, animal data):0.011 mg Ni (as soluble ion)/kg bw/day (770 µg Ni/day for 70 kg person or 231 µg Ni/day of absorbed dose based on 30% absorption of Ni from water under fasting conditions)
LOAEC (inhalation, local, animal data): 0.1 mg Ni/m³ air(powder MMAD=1.8μm, GSD=2.4; Oller et al, 2008)
(Oral, local values are not applicable; Inhalation, systemic values are not applicable; Dermal, local or systemic, values are not applicable)
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEC
- 0.1 mg/m³
Additional information
A 2 -year inhalation carcinogenicity study with nickel metal provides data on repeated dose toxicity. This study concluded that the LOAEC for respiratory effects associated with long-term inhalation exposure to nickel metal powder (MMAD=1.8 μm, GSD=2.4 ) was 0.1 mg/m3.
Repeated dose toxicity of nickel metal via the oral route of exposure is read-across from Ni sulphate (highest nickel bioavailability). A chronic oral exposure study with Ni sulphate yielded a LOAEL of 6.7 mg Ni/kg bw/day and a NOAEL of 2.2 mg Ni/kg bw/day for body weight effects Heim et al., 2007). However, the oral DNEL for long-term systemic effects of Ni ion released from Ni metal (0.011 mg Ni/kg/day) is based on the Tolerable Daily Intake (TDI) for nickel included in the background document for development of WHO (2007) guidelines for drinking water quality. This TDI derived by WHO (2007) is based on the NOAEL for post-implantation loss/perinatal mortality in the one and two-generation studies in rats exposed orally to Ni sulphate (SLI, 2000a,b), and the application of an AF of 10 for intraspecies variability and an AF of 10 for interspecies variability. This TDI is lower than the one that can be derived based on body weight effects in the Heim et al (2007) study. A summary on this topic is provided in Appendix D5 of the CSR.
The following information is taken into account for any hazard / risk assessment:
INHALATION: The LOAEC for respiratory effects associated with inhalation exposure to nickel metal powder (MMAD=1.8 μm, GSD=2.4) was found to be 0.1 mg/m3 in a 2-year bioassay (Oller et al., 2008).
ORAL: Data on lack of chronic oral toxicity are being read-across from Ni sulphate. The oral DNEL for long-term systemic effects of Ni ion (0.011 mg Ni/kg/day) released from nickel metal is based on the TDI for nickel derived by WHO (2007).
DERMAL: Testing by the dermal route has been waived as described above and under Section 7.5.2 of IUCLID.
Justification for classification or non-classification
Ni metal is classified as STOT RE 1; H372 in the 1st ATP to the CLP Regulation. Background information regarding this classification is provided in the discussion section above.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.