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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: observational study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Provided for informational purposes
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Acute nickel intoxication by dialysis.
Author:
Webster JD, Parker TF, Alfrey AC, Smythe WR, Kubo H, Neal G, Hull AR.
Year:
1980
Bibliographic source:
Ann. Intern. Med. 92: 631-633.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
not applicable
Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Nickel(2+) metal
IUPAC Name:
Nickel(2+) metal
Constituent 2
Chemical structure
Reference substance name:
Nickel
EC Number:
231-111-4
EC Name:
Nickel
Cas Number:
7440-02-0
Molecular formula:
Ni
IUPAC Name:
nickel

Results and discussion

Clinical signs:
Nausea, vomiting, weakness, headache, and palpitations were observed after iatrogenic exposure of 23 patients to high levels of nickel during
haemodialysis due to leaching from a nickel-plated, stainless steel, water heating tank. The symptoms were observed at plasma nickel
concentrations of approximately 3 mg Ni/l and disappeared upon cessation of dialysis.

Applicant's summary and conclusion

Conclusions:
Nausea, vomiting, weakness, headache, and palpitations were observed after iatrogenic exposure of 23 patients to high levels of nickel during haemodialysis due to leaching from a nickel-plated, stainless steel, water heating tank. The symptoms were observed at plasma nickel concentrations of approximately 3 mg Ni/l and disappeared upon cessation of dialysis.
Executive summary:

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