Registration Dossier
Registration Dossier
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EC number: 216-653-1 | CAS number: 1634-04-4
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only an abstract is available.
Data source
Reference
- Reference Type:
- publication
- Title:
- Methyl Tertiary-Butyl Ether Induces Alterations In Mouse Testis Weight, Testosterone Production And Morphology.
- Author:
- Almeida L, Hall E
- Year:
- 2 004
- Bibliographic source:
- Toxicologist; 78(1-S):188
Materials and methods
- Principles of method if other than guideline:
- Subacute exposure via drinking water to study effects on male gonads
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- tert-butyl methyl ether
- EC Number:
- 216-653-1
- EC Name:
- tert-butyl methyl ether
- Cas Number:
- 1634-04-4
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methoxy-2-methylpropane
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- continuously
Doses / concentrations
- Remarks:
- Doses / Concentrations:
80, 800, and 8000 ppb
Basis:
other: concentration in drinking water
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 80 other: ppb
- Sex:
- male
- Basis for effect level:
- other: A significant, dose-dependent increase in mean combined testis weight, mean seminal vesicle weight, mean seminiferous tubule diameter, and incidence of abnormal tubules. Serum testosterone was substantially decreased by exposure to 800 and 8000 ppb.
Observed effects
Any other information on results incl. tables
Regarding the Almeida reported findings, a recent study by de Peyster et al. (2008)** which was conducted using the same protocol did not replicate the findings reported by Almeida.
** De Peyster, A, Rodriguez, Y, Shuto, R, Goldberg, B, Gonzales, F, Pu, X, Klaunig, JE. (2008). Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver. Reproductive Toxicology 26(3-4): 246-53.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
