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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Tested substance (isobutane) only relevant as impurity substance.

Data source

Reference
Reference Type:
publication
Title:
Acute inhalation toxicity of some halogenated and non-halogenated hydrocarbons.
Author:
Clark, D.G. and Tinston, D.J.
Year:
1982
Bibliographic source:
Hum Toxicol, 1(3):239-47.

Materials and methods

Principles of method if other than guideline:
Method: other: procedure as detailed in paper by Clark and Tinston (see Reference).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutane
EC Number:
200-857-2
EC Name:
Isobutane
Cas Number:
75-28-5
Molecular formula:
C4H10
IUPAC Name:
isobutane
Details on test material:
IUCLID4 Test substance: other TS

TS-Freetext:
Isobutane, CAS No. 75-28-5

Test animals

Species:
rat

Administration / exposure

Duration of exposure:
15 min

Results and discussion

Effect levels
Dose descriptor:
other: LC50 rat
Effect level:
570 000 ppm
Exp. duration:
15 min
Remarks on result:
other: isobutane

Applicant's summary and conclusion