Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Key value for chemical safety assessment

Additional information

The substance has no structural alerts for mutagenicity. In addition, in vitro studies performed on the substance were GLP compliant, performed according to recommended guidelines and were of a high quality (Klimisch = 1). It is therefore considered that these results are applicable to humans. No further testing is required.

Justification for selection of genetic toxicity endpoint
No study was selected since all three in vitro studies (Klimisch 1) were negative.

Short description of key information:
THe following studies were performed and all showed the test material to be clearly negative both with and without metabolic activation.

Bacterial reverse mutation assay (Ames test) - OECD TG 471
Chromosome Aberration Test in Human Lymphocytes in vitro - OECD TG 473
Mammalian cell gene mutation assay in vitro (mouse lymphoma assay) - OECD TG 476

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Phosphoric acid was found to be negative in all available in vitro gene mutation tests and therefore, the substance should not be classified for mutagenicity.