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Key value for chemical safety assessment

Additional information

The substance has no structural alerts for mutagenicity. In addition, in vitro studies performed on the substance were GLP compliant, performed according to recommended guidelines and were of a high quality (Klimisch = 1). It is therefore considered that these results are applicable to humans. No further testing is required.

Justification for selection of genetic toxicity endpoint
No study was selected since all three in vitro studies (Klimisch 1) were negative.

Short description of key information:
THe following studies were performed and all showed the test material to be clearly negative both with and without metabolic activation.

Bacterial reverse mutation assay (Ames test) - OECD TG 471
Chromosome Aberration Test in Human Lymphocytes in vitro - OECD TG 473
Mammalian cell gene mutation assay in vitro (mouse lymphoma assay) - OECD TG 476

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Phosphoric acid was found to be negative in all available in vitro gene mutation tests and therefore, the substance should not be classified for mutagenicity.