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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute toxicity: oral
A number of Klimisch 4 studies are available, these support the weight of evidence for a classification as category 4.
Acute toxicity: inhalation
No reliable data on phosphoric acid are available for the inhalation route of exposure.
Acute toxicity: dermal
No reliable data on phosphoric acid are available for the dermal route of exposure.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
not specified
GLP compliance:
not specified
Test type:
acute toxic class method
Species:
rat
Strain:
not specified
Sex:
female
Route of administration:
oral: gavage
Doses:
300 and 2000 mg/kg bw
No. of animals per sex per dose:
3 females in duplicate
Sex:
female
Dose descriptor:
LD50
Effect level:
> 300 - < 2 000 mg/kg bw
Based on:
test mat.
Mortality:
At a dose of 2000 mg/kg, 1/3 rats in the first set of animals died, and 2/3 animals dies in the second set of animals dosed with 2000 mg/kg.
Gross pathology:
Necropsy findings in the dead rats were yellow brown or dark fluids in the stomach and adsorption of dark contents in the glandular stomach.

No abnormal signs were seen in the survivors.

Interpretation of results:
harmful
Remarks:
Migrated information EU Category 4 Criteria used for interpretation of results: EU
Conclusions:
The LD50 under the study conditions for Phosphoric acid was concluded to be >300 < 2000 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Quality of whole database:
LD50 > 300 < 2000 mg/kg bw
No reliable studies exist. However, a weight of evidence based on low reliability studies provides sufficient evidence to support classification. In addition as the substance is corrosive no further testing is deemed necessary.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available
Quality of whole database:
No reliable studies are available to assess the acute inhalation toxicity of phosphoric acid.

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available
Quality of whole database:
No reliable studies are available to assess the acute dermal toxicity of phosphoric acid.

Additional information

Acute toxicity: oral

A weight of evidence assessment based on available data is made for the endpoint. As phosphoric acid is classified as corrosive no further testing is proposed. Acute toxicity: inhalation No reliable data are available for phosphoric acid. Acute dermal toxicity No reliable data are available for phosphoric acid. As phosphoric acid is classified as corrosive to the skin it is anticipated that adequated protective measures are in place to prevent exposure via the dermal route.

Justification for selection of acute toxicity – oral endpoint
The WoE on the basis of all studies suggests that the LD50 falls within the range >300 < 2,000 mg/kg bw . The study selected is the one that supports this conclusion and was performed in accordance with the most current guideline.

Justification for selection of acute toxicity – inhalation endpoint
In accordance with Annex VIII, Section 8.5, Column 2 of Regulation No. 1907/2006 (REACH) an acute toxicity test does not need to be conducted if the substance is classified as corrosive to the skin. Phosphoric acid is classified as a skin corrosive (category 1B) and therefore the acute inhalation study does not need to be conducted.

Justification for selection of acute toxicity – dermal endpoint
In accordance with Annex VIII, Section 8.5, Column 2 of Regulation No. 1907/2006 (REACH) an acute toxicity test does not need to be conducted if the substance is classified as corrosive to the skin. Phosphoric acid is classified as a skin corrosive (category 1B) and therefore the acute dermal study does not need to be conducted.

Justification for classification or non-classification

In accordance with Regulation (EC) No. 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures phosphoric acid is classified as acute oral category 4.

In accordance with Regulation (EC) No. 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures phosphoric acid is not considered to be classifed for acute inhalation or dermal effects.