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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary reference - Article from original source not retrieved - based on Payne review
Reason / purpose for cross-reference:
reference to other study

Data source

Reference Type:
secondary source
A method for appraising the stinging capacity of topically applied substances. J Soc Cosmet Chem 28 197-209.
Frosch P J and Kligman A M
Bibliographic source:
Toxicity review 30- Phosphoric acid, Phosphorus pentoxide, Phosphorus oxychloride, Phosphorus pentachloride, Phosphorus pentasulphide; Payne MP, Shillaker RO, Wilson AJ, 1993

Materials and methods

Type of sensitisation studied:
Study type:
study with volunteers
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Orthophosphoric acid
EC Number:
EC Name:
Orthophosphoric acid
Cas Number:
Molecular formula:
phosphoric acid
Details on test material:
Phosphoric acid


Type of population:
not specified
Route of administration:

Results and discussion

Results of examinations:
From Payne review: Stinging sensations following facial application of phosphoric acid during profuse sweating have been studied (Frosch and Kligman 1977). In the c.20% of individuals who demonstrated a high susceptibility to such effects, identified by reactions to topically applied lactic acid, an immediate but transient, generally mild to moderate, stinging response was experienced within the first 10 seconds of exposure to 5% phosphoric acid followed by a more severe stinging sensation 2-5 minutes after exposure. A similarly severe response was experienced on application of 3 ,3% solutions while application ol 1% solutions produced only a slight response. For "non-stingers" 5% phosphoric acid produced a generally mild-moderate stinging sensation 2.5 minutes after exposure. The intensity of stinging and obseruable irritant reactions for a range of chemicals was reported not to be directly correlated.

Applicant's summary and conclusion