Orthophosphoric acid

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Secondary reference - Article from original source not retrieved - based on Payne review

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

secondary source

Title:

A method for appraising the stinging capacity of topically applied substances. J Soc Cosmet Chem 28 197-209.

Author:

Frosch P J and Kligman A M

Year:

1977

Bibliographic source:

Toxicity review 30- Phosphoric acid, Phosphorus pentoxide, Phosphorus oxychloride, Phosphorus pentachloride, Phosphorus pentasulphide; Payne MP, Shillaker RO, Wilson AJ, 1993

Materials and methods

Type of sensitisation studied:

skin

Study type:

study with volunteers

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Orthophosphoric acid

EC Number:

231-633-2

EC Name:

Orthophosphoric acid

Cas Number:

7664-38-2

Molecular formula:

H3O4P

IUPAC Name:

phosphoric acid

Details on test material:

Phosphoric acid

Method

Type of population:

not specified

Route of administration:

dermal

Results and discussion

Results of examinations:

From Payne review: Stinging sensations following facial application of phosphoric acid during profuse sweating have been studied (Frosch and Kligman 1977). In the c.20% of individuals who demonstrated a high susceptibility to such effects, identified by reactions to topically applied lactic acid, an immediate but transient, generally mild to moderate, stinging response was experienced within the first 10 seconds of exposure to 5% phosphoric acid followed by a more severe stinging sensation 2-5 minutes after exposure. A similarly severe response was experienced on application of 3 ,3% solutions while application ol 1% solutions produced only a slight response. For "non-stingers" 5% phosphoric acid produced a generally mild-moderate stinging sensation 2.5 minutes after exposure. The intensity of stinging and obseruable irritant reactions for a range of chemicals was reported not to be directly correlated.