Hydrocarbons, C13-C20, n-alkanes, isoalkanes, cyclic, aromatics (40-60%)

Endpoint summary

Description of key information

Acute Toxicity-Oral LD50 > 4150 mg/kg in rats (OECD TG 401)
Acute Toxicity-Dermal LD50 > 1700 mg/kg in rabbits (OECD TG 402)
Acute Toxicity-Inhalation LC50 > 5.28 mg/L (OECD TG 403)

Additional information

There are no data available for hydrocarbons, C13-C20, n-alkanes, isoalkanes, cyclics, 40-60% aromatics. However, there are data available for the analogue substances C14-C20 aliphatic, 2-30% aromatic hydrocarbon fluids and C11-C20, n-alkanes, isoalkanes, cyclics, aromatics (2-30%). All of the animal studies were performed in a manner similar or equivalent to currently established OECD guidelines.

Oral

Hydrocarbons, C11-C20, n-alkanes, isoalkanes, cyclics, aromatics (2-30%) were tested in a fixed dose procedure by DHC Solvent Chemie GmbH in 1985. No rat died after a single administration of 5 mL/kg bodyweight test substance; converted to 4150 mg/kg bw, by oral gavage. The LD50 value was therefore greater than 4150 mg/kg bw.

Inhalation

The acute toxicity of hydrocarbons, C14-C20 aliphatics (2-30% aromatics) upon inhalation was tested in rats exposed to 5.28 +/- 0.42 mg/L to the whole body as vapour for 4 hours (American Petroleum Institute, 1985). Decreased activity was exhibited by all animals, but no mortality occurred during the exposure. Similar results were concluded from studies of Carpenter et al., summarized by American Petroleum Institute, 2003. No mortalities were observed in rats exposed to saturated vapour for 8 hours. Therefore, the LC50 value in rats was greater than 5.28 mg/L.

Dermal

Hydrocarbons, C11-C20, n-alkanes, isoalkanes, cyclics, aromatics (2-30%) were applied on the trunk of each of five male and five female rats via an occluded patch (DHC Solvent Chemie GmbH, 1985). The patch was removed 24 hours later. The exposure had no effect on viability. The LD50 value was > 2 mL/kg (converted 1.7 g/kg bodyweight). Straight run kerosene (CAS No. 8008-20-6) as undiluted test material was applied to abraded and intact skin of New Zealand White Rabbits (2/sex and dose) (American Petrolium Insitute, 1985). 24 hour exposure to 2 g/kg bw test substance caused hypoactivity and diarrhea as well as some skin effects. No animal died during the study (American Petroleum Institute, 1985). Therefore, the LD50 is higher than 2000 mg/kg bw.

Based on the available read-across data, C13-C20 aliphatic and cyclic, 40-60% aromatic hydrocarbons are considered to have at most a low order of acute toxicity by the oral, dermal, and inhalation routes of exposure.

The following information is taken into account for any hazard / risk assessment:

Acute Toxicity-Oral LD50 > 4150 mg/kg in rats (OECD TG 401)

Acute Toxicity-Dermal LD50 > 1700 mg/kg in rats (OECD TG 402)

Acute Toxicity-Inhalation LC50 > 5.28 mg/L (OECD TG 403)

Justification for classification or non-classification

The available data on the acute toxicity of structurally related substances are conclusive but not sufficient for classification. However, C13-C20 aliphatic and cyclic, 40-60% aromatic hydrocarbons pose an aspiration hazard.

C13-C20, n-alkanes, isoalkanes, cyclics, 40-60% aromatics are classified under EU CLP guidelines as a Category 1 aspiration hazard based on its physical and chemical properties (hydrocarbon fluid, viscosity is 3.86 to 8.88 mm2/s at 20° C≤ 20.5 mm2/s) and as an R65 aspiration hazard under the EU DSD/DPD.