Registration Dossier
Registration Dossier
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EC number: 201-297-1 | CAS number: 80-62-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Method sufficiently described.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 937
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl methacrylate
- EC Number:
- 201-297-1
- EC Name:
- Methyl methacrylate
- Cas Number:
- 80-62-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- methyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Supplier: Dupont
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- oral gavage by measn of a blunt hypodermic needle
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 0.006; 0.007; 0.008; 0.009; 0.010; 0.011; 0.012 ml
- No. of animals per sex per dose:
- 5; 10; 10; 10; 10; 10; 5
sex not specified - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 8 500 - ca. 9 400 mg/kg bw
- Mortality:
- observed
- Other findings:
- Twenty to forty minutes after oral treatment all rats showed a more ar less pronounced dyspnea fom which some did not recover after twentyfour hours later, while others died within this time.
Applicant's summary and conclusion
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