Methyl methacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Method sufficiently described.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1937

Materials and methods

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methyl methacrylate

EC Number:

201-297-1

EC Name:

Methyl methacrylate

Cas Number:

80-62-6

Molecular formula:

C5H8O2

IUPAC Name:

methyl 2-methylprop-2-enoate

Test material form:

liquid

Specific details on test material used for the study:

Supplier: Dupont

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

oral gavage by measn of a blunt hypodermic needle

Administration / exposure

Route of administration:

oral: gavage

Doses:

0.006; 0.007; 0.008; 0.009; 0.010; 0.011; 0.012 ml

No. of animals per sex per dose:

5; 10; 10; 10; 10; 10; 5
sex not specified

Control animals:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

approximate LD50

Effect level:

ca. 8 500 - ca. 9 400 mg/kg bw

Mortality:

observed

Other findings:

Twenty to forty minutes after oral treatment all rats showed a more ar less pronounced dyspnea fom which some did not recover after twentyfour hours later, while others died within this time.